Arash,
No, not directly. Here is an image of the full moon with the 500 and canon 2x TC:
http://www.clarkvision.com/galleries...3f-8s-800.html
Use of TCs on the supertelephotos can appear soft, but it is usually technique because the extreme magnification is amplifying all the little shaking, even with IS. I did get a new appreciation for the sharpness of the 500 when I started using the 5DII. The blur filter on the 5DII is not as aggressive as on the 1DII, so images appear significantly sharper at the pixel level on the 5DII, but I have seen more edge artifacts too. Those artifacts are pretty small, and overall image quality is amazing. But if you try and image a planet, like Jupiter or Venus with the 500 and a TC, some images will have little protrusions out the edge of the planet due to the rectangular sampling (jaggies).
Summary, 500 f/4 L IS + 1.4 or 2x TC is impressively sharp, but it sometimes tiny vibrations to rob some of that sharpness, so one needs superb technique to prevent that. A 600 would be even tougher because magnification is more.
Roger