I would say if one wants a rule of thumb, for best S/N it's ETTR
at the lowest possible ISO up to ISO 1600 (or even 800, since the gains are really marginal between 800 and 1600). By lowest possible ISO, I mean that a lower bound on shutter speed may be set by the desire to freeze motion (subject or camera); then one moves the histogram to the right by increasing the ISO, up to 1600; if that requisite shutter speed demands an ISO above 1600, instead keep the ISO fixed at 1600,
underexpose and adjust in post-processing -- the S/N will be
the same as "proper" exposure at ISO above 1600, and there is more dynamic range in highlights.